Renal sodium handling and sodium sensitivity
نویسندگان
چکیده
منابع مشابه
Renal sodium handling and sodium sensitivity
The pathophysiology of hypertension, which affects over 1 billion individuals worldwide, involves the integration of the actions of multiple organ systems, including the kidney. The kidney, which governs sodium excretion via several mechanisms including pressure natriuresis and the actions of renal sodium transporters, is central to long term blood pressure regulation and the salt sensitivity o...
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T he epithelial sodium channel (ENaC) is a critically important final regulator of the balance between intake and excretion of dietary sodium (1), and along with the thiazide-sensitive NaCl co-transporter constitutes the predominant sodium transport systems in the aldosterone-sensitive distal nephron (2). The use of the oocyte expression system for cloning the ENaC subunits was a technical tour...
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The circadian clock contributes to the control of BP, but the underlying mechanisms remain unclear. We analyzed circadian rhythms in kidneys of wild-type mice and mice lacking the circadian transcriptional activator clock gene. Mice deficient in clock exhibited dramatic changes in the circadian rhythm of renal sodium excretion. In parallel, these mice lost the normal circadian rhythm of plasma ...
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ژورنال
عنوان ژورنال: Kidney Research and Clinical Practice
سال: 2017
ISSN: 2211-9140
DOI: 10.23876/j.krcp.2017.36.2.117